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Literature summary for 1.11.1.9 extracted from

  • Branco, V.; Canario, J.; Lu, J.; Holmgren, A.; Carvalho, C.
    Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase (2012), Free Radic. Biol. Med., 52, 781-793.
    View publication on PubMed
Search for more literature for 1.11.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Diplodus cervinus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + H2O2 Diplodus cervinus
-
 glutathione disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Diplodus cervinus
-
 zebra-seabream
-

Source Tissue

Source Tissue Comment Organism Textmining
brain highest expression Diplodus cervinus
-
kidney
-
 Diplodus cervinus
-
liver
-
 Diplodus cervinus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + H2O2
-
 Diplodus cervinus glutathione disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
glutathione:hydrogen-peroxide oxidoreductase
-
 Diplodus cervinus
GPX
-
 Diplodus cervinus
SeGPx
-
 Diplodus cervinus
seleno-dependent glutathione peroxidase 1
-
 Diplodus cervinus

Expression

Organism Comment Expression
Diplodus cervinus in the brain, enzyme activity is significantly inhibited (51% after 28 days) during methylmercury exposure. In the case of co-exposure to methylmercury and selenium, inhibition of enzyme activity is less pronounced (25% at day 28) down