Activating Compound | Comment | Organism | Structure |
---|---|---|---|
betanin | low micromolar betanin concentrations enhance the chlorination activity of MPO at pH 7.0, increasing the betanin concentration up to 0.006 mM dramatically increases the chlorination rate of monochlorodimedon | Homo sapiens | |
indicaxanthin | at neutral pH and depending on their concentration, indicaxanthin can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
betanin | higher micromolar betanin concentrations inhibit the MPO-mediated chlorination reactions by scavenging of hypochlorous acid | Homo sapiens | |
indicaxanthin | at neutral pH and depending on their concentration, indicaxanthin can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO, whereas at pH 5.0 only inhibitory effects are observed even at micromolar concentrations | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 | Homo sapiens | - |
HClO + H2O | - |
? | |
monochlorodimedon + Cl- | Homo sapiens | - |
dichlorodimedon | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 | - |
Homo sapiens | HClO + H2O | - |
? | |
monochlorodimedon + Cl- | - |
Homo sapiens | dichlorodimedon | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MPO | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |