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Literature summary for 1.11.2.2 extracted from

  • Coker, M.; Forbes, L.; Plowman-Holmes, M.; Murdoch, D.; Winterbourn, C.; Kettle, A.
    Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species (2018), Arch. Biochem. Biophys., 646, 80-89 .
    View publication on PubMed
Search for more literature for 1.11.2.2

Inhibitors

Inhibitors Comment Organism Structure
2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyrimidine-5-carbohydroxamic acid HX1, reversible inhibition Homo sapiens
3-isobutyl-2-thioxo-7H-purin-6-one TX1 Homo sapiens
additional information enterobactin is not an inhibitor of myeloperoxidase Homo sapiens
staphyloxanthin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
 HClO + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05164
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?
L-tyrosine + H2O2 + H+
-
 Homo sapiens ?
-
 ?
thiocyanate + H2O2 + H+
-
 Homo sapiens ?
-
 ?
urate + H2O2 + H+
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003
-
 at pH 7.4, temperature not specified in the publication Homo sapiens 2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyrimidine-5-carbohydroxamic acid
0.0006
-
 at pH 7.4, temperature not specified in the publication Homo sapiens 3-isobutyl-2-thioxo-7H-purin-6-one

General Information

General Information Comment Organism
physiological function myeloperoxidase is a key player in oxidative killing of bacteria. This enzyme uses superoxide and hydrogen peroxide to generate hypochlorous acid - a strong oxidant that is toxic to all bacteria Homo sapiens