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Literature summary for 1.11.2.2 extracted from

  • Santos, M.B.D.; Carvalho Marques, B.; Miranda Ayusso, G.; Rocha Garcia, M.A.; Chiquetto Paracatu, L.; Pauli, I.; Silva Bolzani, V.; Defini Andricopulo, A.; Farias Ximenes, V.; Zeraik, M.L.; Regasini, L.O.
    Chalcones and their B-aryl analogues as myeloperoxidase inhibitors In silico, in vitro and ex vivo investigations (2021), Bioorg. Chem., 110, 104773 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(2Z)-1-(2-aminophenyl)-3-phenylprop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(3-aminophenyl)-3-phenylprop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-(furan-2-yl)prop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-(naphthalen-1-yl)prop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-(naphthalen-2-yl)prop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-(thiophen-2-yl)prop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one
-
 Homo sapiens
(2Z)-1-(4-aminophenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
-
 Homo sapiens
4-[(1Z)-3-(4-aminophenyl)-3-oxoprop-1-en-1-yl]benzonitrile
-
 Homo sapiens
5-fluorotryptamine
-
 Homo sapiens
Salicylhydroxamic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
 HClO + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05164
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00052
-
 at 37°C, pH not specified in the publication Homo sapiens 4-[(1Z)-3-(4-aminophenyl)-3-oxoprop-1-en-1-yl]benzonitrile
0.00053
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-(thiophen-2-yl)prop-2-en-1-one
0.00054
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-(furan-2-yl)prop-2-en-1-one
0.00056
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
0.00056
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one
0.00063
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one
0.00063
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
0.00097
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(3-aminophenyl)-3-phenylprop-2-en-1-one
0.00105
-
 at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(2-aminophenyl)-3-phenylprop-2-en-1-one
0.01
-
 IC50 above 0.01 mM, at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-(naphthalen-1-yl)prop-2-en-1-one
0.01
-
 IC50 above 0.01 mM, at 37°C, pH not specified in the publication Homo sapiens (2Z)-1-(4-aminophenyl)-3-(naphthalen-2-yl)prop-2-en-1-one
0.0101
-
 at 37°C, pH not specified in the publication Homo sapiens 5-fluorotryptamine