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Literature summary for 1.11.2.2 extracted from

  • Thai, T.; Zhong, F.; Dang, L.; Chan, E.; Ku, J.; Malle, E.; Geczy, C.L.; Keaney, J.F.; Thomas, S.R.
    Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway (2021), Free Radic. Biol. Med., 166, 255-264 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
 HClO + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05164
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function stimulation of endothelial-transcytosed enzyme activates endothelial nitric oxide synthase (eNOS) by promoting phospholipase C-dependent calcium signaling and altered eNOS phosphorylation at Ser-1179 and Thr-497. This may constitute a compensatory signaling response of endothelial cells aimed at maintaining eNOS activity and nitric oxide production in the face of enzyme-catalyzed oxidative stress Homo sapiens