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Literature summary for 1.12.98.2 extracted from
- Comprehensive computational analysis of Hmd enzymes and paralogs in methanogenic Archaea (2009), BMC Evol. Biol., 9, 199-210.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe | Hmd holoenzyme is comprised of 2 iron atoms, each iron atom coordinates the reduction of methenyltetrahydromethanopterin and oxidation of H2 while bound to both Hmd and a cofactor molecule | Methanocaldococcus jannaschii |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38000 | - |
the Hmd holoenzyme is comprised of a homodimer of 38 kDa subunits, 2 pyridone derivative cofactor molecules and 2 iron atoms | Methanocaldococcus jannaschii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methenyltetrahydromethanopterin + H2 | Methanocaldococcus jannaschii | Hmd catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens | 5,10-methylenetetrahydromethanopterin + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanocaldococcus jannaschii | Q58194 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methenyltetrahydromethanopterin + H2 | Hmd catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens | Methanocaldococcus jannaschii | 5,10-methylenetetrahydromethanopterin + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 38000, structural modeling of Hmd enzyme reveals a common structural arrangement comprised of one large N-terminal domain containing alpha-helices and beta-sheets and one smaller C-terminal domain containing only alpha-helices | Methanocaldococcus jannaschii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| H2-forming methylenetetrahydromethanopterin dehydrogenase | - |
Methanocaldococcus jannaschii |
| Hmd | - |
Methanocaldococcus jannaschii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| coenzyme F420 | - |
Methanocaldococcus jannaschii | |
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Release 2023.1 (January 2023)
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