Literature summary for 1.13.11.11 extracted from

Gonzalez Esquivel, D.; Ramirez-Ortega, D.; Pineda, B.; Castro, N.; Rios, C.; Perez de la Cruz, V.
Kynurenine pathway metabolites and enzymes involved in redox reactions (2017), Neuropharmacology, 112, 331-345 .

Activating Compound

Activating Compound	Comment	Organism	Structure
H2O2	activation of the enzyme is stimulated by superoxide and H2O2	Homo sapiens
superoxide	activation of the enzyme is stimulated by superoxide and H2O2	Homo sapiens

Inhibitors	Comment	Organism
3-hydroxykynurenine	-	Homo sapiens
Cu2+	-	Homo sapiens
cyanide	-	Homo sapiens

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.02	-	L-tryptophan	pH and temperature not specified in the publication	Homo sapiens
0.19	-	L-tryptophan	pH and temperature not specified in the publication	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P14902	-	-
Homo sapiens	P48775	-	-
Homo sapiens	Q6ZQW0	-	-
Mus musculus	P28776	-	-
Xanthomonas campestris pv. campestris	Q8PDA8	-	-
Xanthomonas campestris pv. campestris ATCC 33913	Q8PDA8	-	-

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Mus musculus	-
astrocyte	-	Homo sapiens	-
brain	expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes	Mus musculus	-
brain	expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes	Homo sapiens	-
kidney	-	Mus musculus	-
kidney	-	Homo sapiens	-
large intestine	-	Mus musculus	-
large intestine	-	Homo sapiens	-
liver	-	Mus musculus	-
liver	-	Homo sapiens	-
liver	low level expression	Homo sapiens	-
liver	the enzyme is located in the oxygene-rich environment of the liver promoting greater amount of the enzyme in ferric form than in ferrous form, which could contribute to the binding to substrates occurs in this form	Homo sapiens	-
lung	-	Mus musculus	-
lung	-	Homo sapiens	-
macrophage	-	Mus musculus	-
macrophage	-	Homo sapiens	-
microglia	-	Mus musculus	-
microglia	-	Homo sapiens	-
additional information	in human tumors IDO-2 is expressed, but it is produced in a functionally inactive form	Homo sapiens	-
neuron	-	Mus musculus	-
neuron	-	Homo sapiens	-
placenta	-	Mus musculus	-
placenta	-	Homo sapiens	-
small intestine	-	Mus musculus	-
small intestine	-	Homo sapiens	-
spleen	-	Mus musculus	-
spleen	-	Homo sapiens	-
stomach	-	Mus musculus	-
stomach	-	Homo sapiens	-
testis	low level expression	Homo sapiens	-
thyroid	low level expression	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
L-tryptophan + O2	-	Homo sapiens	N-formyl-L-kynurenine	-	?
L-tryptophan + O2	the enzyme has broad substrate specificity for various indoleamines such as L-tryptophan and serotonin. It catalyzes the oxidation of the pyrrole ring of tryptophan to form N-formylkynurenine, which is later metabolized to formic acid and kynurenine	Mus musculus	N-formyl-L-kynurenine	-	?
L-tryptophan + O2	the enzyme has broad substrate specificity for various indoleamines such as L-tryptophan and serotonin. It catalyzes the oxidation of the pyrrole ring of tryptophan to form N-formylkynurenine, which is later metabolized to formic acid and kynurenine	Homo sapiens	N-formyl-L-kynurenine	-	?

Subunits	Comment	Organism
tetramer	-	Homo sapiens
tetramer	-	Xanthomonas campestris pv. campestris

Cofactor	Comment	Organism
heme	heme-containing enzyme	Mus musculus
heme	heme-containing enzyme	Homo sapiens
heme	heme-containing enzyme	Xanthomonas campestris pv. campestris
heme	heme-containing enzyme. The heme prosthetic group is present as a heme-ferric form that must be reduced to the heme-ferrous prior to mediate L-tryptophan oxidation	Homo sapiens
heme	the enzyme is heme dependent, requiring the reduction of ferric to ferrous-iron to bind to L-tryptophan	Homo sapiens