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Literature summary for 1.13.11.11 extracted from
- Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinsons disease (2021), Expert Opin. Ther. Targets, 25, 877-888 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P48775 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDO | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| drug target | tryptophan 2,3-dioxygenase is a therapeutic target for Parkinson's disease | Homo sapiens |
| malfunction | alterations in the activity of tryptophan 2,3-dioxygenase cause imbalances in the levels of serotonin and other neuroactive metabolites which can contribute to motor, psychiatric, gastrointestinal, and other dysfunctions often seen in Parkinson's disease | Homo sapiens |
| physiological function | tryptophan 2,3-dioxygenase is a key enzyme of tryptophan metabolism at the entry of the kynurenine pathway which moderates production of neuroactive compounds primarily outside the central nervous system | Homo sapiens |
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Release 2023.1 (January 2023)
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