Literature summary for 1.13.11.12 extracted from

Horowitz Brown, S.; Zarnowski, R.; Sharpee, W.C.; Keller, N.P.
Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus (2008), Appl. Environ. Microbiol., 74, 5674-5685.

Search for more literature for 1.13.11.12

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of lox greatly diminishes density-dependent development of both sclerotia and conidia, resulting in an overall increase in the number of sclerotia and a decrease in the number of conidia at high cell densities. Lox mutants show decreased linoleic acid LOX activity	Aspergillus flavus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe	the iron atom in LOX is bound by four ligands, three of which are histidine residues	Aspergillus flavus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus flavus	B5SXD0	strains NRRL 3357, TSHB3.1C and TSHB3.5C	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
linoleic acid + O2	-	Aspergillus flavus	(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid	-	?

Synonyms

Synonyms	Comment	Organism
LOX	-	Aspergillus flavus

Expression

Organism	Comment	Expression
Aspergillus flavus	Lox is a low-expression gene, no expression in wild-type strain NRRL 3357	down
Aspergillus flavus	Lox is expressed in the complemented strains TSHB3.1C and TSHB3.5C. While complemented strain TSHB3.1C (harboring a single-copy insertion) expresses a clear transcript, complemented strain TSHB3.5C (harboring at least two copies of lox and likely more) produces a greatly increased transcript and also produces an additional smaller band, which is absent in the single-copy strain TSHB3.1C	up

General Information

General Information	Comment	Organism
malfunction	deletion of lox greatly diminishes density-dependent development of both sclerotia and conidia, resulting in an overall increase in the number of sclerotia and a decrease in the number of conidia at high cell densities. Lox mutants show decreased linoleic acid LOX activity	Aspergillus flavus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)