Literature summary for 1.13.11.12 extracted from

Goftari, S.N.; Sadeghian, H.; Bahrami, A.R.; Maleki, F.; Matin, M.M.
Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors (2019), Naunyn Schmiedebergs Arch. Pharmacol., 392, 1491-1502 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine	-	Homo sapiens
adamantyl caffeate	IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.074 mM	Homo sapiens
bornyl vanillate	IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.401 mM	Homo sapiens
fenchyl caffeate	IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.089 mM	Homo sapiens
additional information	stylosin and some similar synthetic monoterpenoids show inhibitory effects on 15-LOX. A strong positive correlation is observed between 15-LOX inhibition potential and cytotoxicity of the compounds with apoptosis being the predominant mechanism of induced cell death	Homo sapiens
stylosin	IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.101 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16050	cf. EC 1.13.11.31, EC 1.13.11.33	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Homo sapiens	-
PC-3 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
linoleate + O2	-	Homo sapiens	(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate	-	?

Synonyms

Synonyms	Comment	Organism
15-LOX-1	-	Homo sapiens
Alox15	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.011	-	pH 7.0, 25°C	Homo sapiens	fenchyl caffeate
0.0171	-	pH 7.0, 25°C	Homo sapiens	4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
0.0261	-	pH 7.0, 25°C	Homo sapiens	adamantyl caffeate
0.0668	-	pH 7.0, 25°C	Homo sapiens	stylosin
0.399	-	pH 7.0, 25°C	Homo sapiens	bornyl vanillate

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Release 2023.1 (January 2023)