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Literature summary for 1.13.11.15 extracted from

  • Tu, N.; Zhang, D.; Niu, X.; Du, C.; Zhang, L.; Xie, W.; Niu, X.; Liu, Y.; Li, Y.
    A novel concept for the biodegradation mechanism of dianionic catechol with homoprotocatechuate 2,3-dioxygenase A non-proton-assisted process (2020), Chemosphere, 246, 125796 .
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
H200N variant employs a C4 (para-carbon) pathway to produce a C4-C5 cleavage product Brevibacterium fuscum

Organism

Organism UniProt Comment Textmining
Brevibacterium fuscum Q45135
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrocatechol + O2
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 Brevibacterium fuscum (2Z,4Z)-2-hydroxy-4-nitro-6-oxohexa-2,4-dienoate
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 ?
4-nitrocatechol + O2
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 Brevibacterium fuscum (2Z,4Z)-2-hydroxy-5-nitro-6-oxohexa-2,4-dienoate
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 ?

General Information

General Information Comment Organism
metabolism the catalytic reaction with substrate 4-nitrocatechol is comprised of four steps: (1) A dioxygen attacks the aromatic ring to produce an alkylperoxo species. (2) O-O bond cleavage and the formation of an epoxide species occur. (3) A seven-membered O-heterocyclic compound is generated by the extinction of the epoxy structure. (4) The seven-membered ring undergoes ring opening to form the final product (C2-C3 cleavage product). The effective free energy barrier of the catalytic reaction of the system is 26.2 kcal/mol Brevibacterium fuscum