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Literature summary for 1.13.11.16 extracted from

  • Sainsbury, P.D.; Mineyeva, Y.; Mycroft, Z.; Bugg, T.D.
    Chemical intervention in bacterial lignin degradation pathways development of selective inhibitors for intradiol and extradiol catechol dioxygenases (2015), Bioorg. Chem., 60, 102-109 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(3,4-dihydroxyphenyl)-N-[(4-fluorophenyl)methyl]-N-hydroxyacetamide over 90% inhibition at 0.25 mM Rhodococcus jostii
N-benzyl-3-(3,4-dimethoxyphenyl)-N-hydroxypropanamide 25% inhibition at 0.25 mM Rhodococcus jostii

Organism

Organism UniProt Comment Textmining
Rhodococcus jostii
-
-
-

Synonyms

Synonyms Comment Organism
2,3-dihydroxyphenylpropionate 1,2-dioxygenase
-
Rhodococcus jostii
MhpB
-
Rhodococcus jostii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rhodococcus jostii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rhodococcus jostii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.11
-
pH 7.5, 37°C Rhodococcus jostii 2-(3,4-dihydroxyphenyl)-N-[(4-fluorophenyl)methyl]-N-hydroxyacetamide