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Literature summary for 1.13.11.19 extracted from
- Enhancing tris(pyrazolyl)borate-based models of cysteine/cysteamine dioxygenases through steric effects increased reactivities, full product characterization and hints to initial superoxide formation (2020), Chemistry, 26, 11851-11861 .
Organism
| Organism | UniProt | Comment | Textmining |
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| synthetic construct | - |
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General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | design of biomimetic model complexes where the 3-His coordination of the iron ion is simulated by three pyrazole donors of a trispyrazolyl borate ligand and protected cysteamine represent substrate ligands. Replacement of phenyl groups attached at the 3-positions of the pyrazole units in a previous model by mesityl residues has massive consequences, as the latter arrange to a more spacious reaction pocket. The reaction with O2 proceeds much faster and the structural characterization of an iron(II) eta2-O,O-sulfinate product became possible | synthetic construct |
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