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Literature summary for 1.13.11.20 extracted from

  • Stipanuk, M.H.; Hirschberger, L.L.; Londono, M.P.; Cresenzi, C.L.; Yu, A.F.
    The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver (2004), Am. J. Physiol., 286, E439-448.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Hep-G2 cells Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ metalloenzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + O2 Rattus norvegicus key enzyme in sulfate production, critical regulator of cellular cysteine concentration and availability of cysteine for anabolic processes 3-sulfino-L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Sprague-Dawley rats, very low activity in animals fed a low protein diet, high level of enzyme in animals fed a protein, methionine, or cysteine rich diet
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Source Tissue

Source Tissue Comment Organism Textmining
brain lower level than in liver Rattus norvegicus
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hepatocyte primary cell culture, high enzyme activity in cysteine rich medium Rattus norvegicus
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kidney lower level than in liver Rattus norvegicus
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liver
-
 Rattus norvegicus
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lung lower level than in liver Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + O2
-
 Rattus norvegicus 3-sulfino-L-alanine
-
 ?
L-cysteine + O2 key enzyme in sulfate production, critical regulator of cellular cysteine concentration and availability of cysteine for anabolic processes Rattus norvegicus 3-sulfino-L-alanine
-
 ?