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Literature summary for 1.13.11.20 extracted from
- Comparison of the sulfur-oxygenation of cysteine and S-carboxymethyl-l-cysteine in human hepatic cytosol and the role of cysteine dioxygenase (2018), J. Pharm. Pharmacol., 70, 1069-1077 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NADH | enzyme uses NAD+/NADH as pharmacological chaperone. Presence of 0.1 mM NADH increase activity 1.3fold | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibitory: S-carboxymethyl-L-cysteine | Homo sapiens | |
| NADP+ | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.51 | - |
L-cysteine | pH 6, 37°C | Homo sapiens | |
| 8.21 | - |
S-carboxymethyl-L-cysteine | pH 6, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | required, maximum activity at 0.5 mM Fe2+ | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16878 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-cysteine + O2 | - |
Homo sapiens | 3-sulfino-L-alanine | - |
? | |
| S-carboxymethyl-L-cysteine + O2 | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDO1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | enzyme uses NAD+/NADH as pharmacological chaperone | Homo sapiens | |
| NADH | enzyme uses NAD+/NADH as pharmacological chaperone. Presence of 0.1 mM NADH increase activity 1.3fold | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | hepatic cytosolic fraction cysteine dioxygenase activity is not responsible for the S-oxidation of the substituted cysteine, S-carboxymethyl-L-cysteine | Homo sapiens |
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