Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.24 extracted from

  • Fusetti, F., Schröter, K.H.; Steiner, R.A.; van Noort, P.I.; Pijning, T.; Rozeboom, H.J.; Kalk, K.H.; Egmond, M.R.; Dijkstra, B.W.
    Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus (2002), Structure, 2, 259-268.
    View publication on PubMed
Search for more literature for 1.13.11.24

Crystallization (Commentary)

Crystallization (Comment) Organism
copper-containing quercetin 2,3-dioxygenase, X-ray diffraction structure determination and analysis at 1.6 A resolution Aspergillus japonicus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ required, enzyme-bound, structure, overview. Manual docking, different geometries of the copper site Aspergillus japonicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Aspergillus japonicus quercetin 2,3-dioxygenase is a copper-containing enzyme that catalyzes the insertion of molecular oxygen into polyphenolic flavonols ?
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus japonicus Q7SIC2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information quercetin 2,3-dioxygenase is a copper-containing enzyme that catalyzes the insertion of molecular oxygen into polyphenolic flavonols Aspergillus japonicus ?
-
 ?

Subunits

Subunits Comment Organism
homodimer he enzyme forms homodimers, which are stabilized by an N-linked heptasaccharide at the dimer interface. The mononuclear type 2 copper center displays two distinct geometries: a distorted tetrahedral coordination, formed by His66, His68, His112, and a water molecule, and a distorted trigonal bipyramidal environment, which additionally comprises Glu73. Manual docking of the substrate quercetin into the active site showed that the different geometries of the copper site might be of catalytic importance Aspergillus japonicus

General Information

General Information Comment Organism
additional information Manual docking of the substrate quercetin into the active site showed that the different geometries of the copper site might be of catalytic importance Aspergillus japonicus