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Literature summary for 1.13.11.25 extracted from
- Nonheme iron dioxygenase (1974), Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York, , 135-165.
No PubMed abstract available
General Stability
| General Stability | Organism |
|---|---|
| acetone stabilizes | Rhodococcus equi |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,2'-dipyridyl | noncompetitive inhibition | Rhodococcus equi |  |
| 4-hydroxymercuribenzoate | 1 mM, 87% inhibition after 10 min | Rhodococcus equi | |
| 4-Isopropylcatechol | competitive vs. organic substrate, uncompetitive vs. O2 | Rhodococcus equi | |
| 8-hydroxyquinoline | 1 mM, 90% inhibition after 10 min, noncompetitive inhibition | Rhodococcus equi | |
| o-phenanthroline | 1 mM, 68% inhibition after 10 min, noncompetitive inhibition | Rhodococcus equi | |
| sodium iodoacetate | 1 mM, 70% inhibition after 10 min | Rhodococcus equi | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | 1.13 gatom per mol of enzyme, stimulation of reaction | Rhodococcus equi | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 286000 | - |
- |
Rhodococcus equi |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 | Rhodococcus equi | - |
3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rhodococcus equi | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate | proximal extradiol cleavage | Rhodococcus equi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 | - |
Rhodococcus equi | 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate | - |
? | |
| 3-isopropylcatechol + O2 | - |
Rhodococcus equi | ? | - |
? | |
| 3-tert-butyl-5-methylcatechol + O2 | - |
Rhodococcus equi | ? | - |
? | |
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