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Literature summary for 1.13.11.26 extracted from
- Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin (1998), Life Sci., 62, 2417-2423.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| desipramine | antidepressant, exogenous melatonin counteracts the inhibitory effect | Rattus norvegicus |  |
| fluoxetine | antidepressant, exogenous melatonin counteracts the inhibitory effect | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar, male | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | - |
Rattus norvegicus | formylkynurenine | - |
? | |
| tryptophan + O2 | - |
Rattus norvegicus | L-kynurenine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
enzyme assay | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| hemin | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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