BRENDA - Enzyme Database show
show all sequences of 1.13.11.27

Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway

Serre, L.; Sailland, A.; Sy, D.; Boudec, P.; Rolland, A.; Pebay-Peyroula, E.; Cohen-Addad, C.; Structure Fold. Des. 7, 977-988 (1999)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
hanging-drop method in 18-25% PEG 4000, 0.2 M ammonium acetate, 0.1 M trisodium citrate, pH 5.6, at room temperature
Pseudomonas sp.
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Iron
one non-heme iron atom per monomer liganded to the sidechains of His161, His240, Glu322 and one acetate molecule
Pseudomonas sp.
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas sp.
-
-
-
Purification (Commentary)
Commentary
Organism
recombinant enzyme expressed in Escherichia coli
Pseudomonas sp.
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-hydroxyphenylpyruvate + O2
-
395395
Pseudomonas sp.
homogentisate + CO2
-
-
-
?
Crystallization (Commentary) (protein specific)
Crystallization
Organism
hanging-drop method in 18-25% PEG 4000, 0.2 M ammonium acetate, 0.1 M trisodium citrate, pH 5.6, at room temperature
Pseudomonas sp.
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Iron
one non-heme iron atom per monomer liganded to the sidechains of His161, His240, Glu322 and one acetate molecule
Pseudomonas sp.
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme expressed in Escherichia coli
Pseudomonas sp.
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-hydroxyphenylpyruvate + O2
-
395395
Pseudomonas sp.
homogentisate + CO2
-
-
-
?
Other publictions for EC 1.13.11.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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39
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743211
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Molecular insight into the in ...
Arabidopsis thaliana, Rattus norvegicus
Med. Chem. Res.
24
3958-3971
2015
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12
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2
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2
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2
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6
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6
12
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2
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2
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2
2
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743407
Wang
Design, synthesis and herbici ...
Arabidopsis thaliana
Pest Manag. Sci.
71
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2015
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1
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40
-
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1
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1
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3
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1
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1
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1
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1
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35
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2
1
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40
35
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1
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1
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1
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1
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1
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1
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1
1
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743564
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The inhibitory activity of pl ...
Sus scrofa
Planta Med.
81
1382-1391
2015
-
-
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1
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1
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1
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4
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2
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1
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1
1
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727448
Frick
Structural and functional char ...
Picrophilus torridus, Picrophilus torridus DSM 9790
Extremophiles
18
641-651
2014
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1
1
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-
17
1
-
-
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2
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6
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1
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6
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1
2
2
1
2
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1
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1
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17
1
1
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2
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1
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6
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1
2
2
1
2
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1
1
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1
1
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98
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2
1
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5
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1
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3
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1
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1
1
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1
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741762
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544
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2014
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3
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1
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14
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5
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6
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6
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5
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6
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14
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6
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1
12
12
1
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742056
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1
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2
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742068
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22
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2014
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2
1
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46
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1
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1
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2
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1
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1
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1
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1
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46
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2
1
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46
46
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1
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1
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1
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1
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1
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742722
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62
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1
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1
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1
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4
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1
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2
2
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742742
Wojcik
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Pseudomonas fluorescens, Pseudomonas fluorescens ATCC 13525
J. Am. Chem. Soc.
136
14472-14485
2014
-
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1
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1
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2
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5
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1
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1
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2
2
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724392
Shah
Intermediate partitioning kine ...
Streptomyces avermitilis
Biochemistry
52
6097-6107
2013
-
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1
-
6
-
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1
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1
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1
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1
1
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1
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1
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1
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1
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6
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1
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1
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1
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1
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1
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1
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1
1
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726347
Lin
The interactions in the carbox ...
Homo sapiens
PLoS ONE
8
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2013
-
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1
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5
-
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7
-
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1
1
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3
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1
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1
6
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2
2
1
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7
1
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1
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5
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7
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1
1
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1
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1
6
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2
2
1
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7
1
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4
4
-
8
8
724325
Shah
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Streptomyces avermitilis
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50
7694-7704
2011
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1
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4
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4
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1
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1
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1
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1
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1
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1
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4
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1
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1
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5
1
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5
5
725432
Raspail
4-hydroxyphenylpyruvate dioxyg ...
Arabidopsis thaliana, Daucus carota, Pseudomonas fluorescens, Streptomyces avermitilis
J. Biol. Chem.
286
26061-26070
2011
-
-
-
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11
-
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6
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4
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6
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4
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4
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4
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11
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5
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4
4
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728561
Bally
Metabolic adaptation in transp ...
Pseudomonas fluorescens
PLoS ONE
6
e25289
2011
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1
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701453
Molchanov
Inhibition of 4-hydroxyphenylp ...
Pseudomonas fluorescens
Acta Biochim. Pol.
56
447-454
2009
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-
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1
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1
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2
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703344
He
We two alone will sing: the tw ...
Pseudomonas fluorescens
Curr. Opin. Chem. Biol.
13
436-443
2009
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1
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703740
Turick
The role of 4-hydroxyphenylpyr ...
Shewanella oneidensis, Shewanella oneidensis MR-1 / ATCC 700550
FEMS Microbiol. Ecol.
68
223-225
2009
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1
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1
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1
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4
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704130
Dayan
Beta-triketone inhibitors of p ...
Arabidopsis thaliana
J. Agric. Food Chem.
57
5194-5200
2009
-
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1
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-
19
-
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4
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1
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19
-
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1
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19
19
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1
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705631
Xiao
Characterization and expressio ...
Salvia miltiorrhiza
Mol. Biol. Rep.
36
2019-2029
2009
-
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1
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1
1
1
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4
-
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4
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1
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The 1-deoxy-D: -xylulose 5-pho ...
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Identification of a novel 4-hy ...
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The tyrosine degradation gene ...
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Grossmann
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Dayan
p-Hydroxyphenylpyruvate dioxyg ...
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Phytochemistry
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Purpero
Catalytic, noncatalytic, and i ...
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Biochemistry
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672033
Johnson-Winters
Accumulation of multiple inter ...
Streptomyces avermitilis
Biochemistry
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Falk
Characterization of transplast ...
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Lederer
Recombinant p-hydroxyphenylpyr ...
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658016
Yang
Structural basis for herbicida ...
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Biochemistry
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Borowski
4-Hydroxyphenylpyruvate dioxyg ...
Pseudomonas fluorescens
Biochemistry
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2004
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658078
Brownlee
Structure of the ferrous form ...
Streptomyces avermitilis
Biochemistry
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6370-6377
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658081
Gunsior
Engineering p-hydroxyphenylpyr ...
Streptomyces avermitilis
Biochemistry
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663-674
2004
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658980
Neidig
CD and MCD studies of the non- ...
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660236
Fritze
The crystal structures of Zea ...
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657941
Kavana
Interaction of (4-hydroxypheny ...
Streptomyces avermitilis
Biochemistry
42
10238-10245
2003
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657978
Johnson-Winters
(4-Hydroxyphenyl)pyruvate diox ...
Streptomyces avermitilis
Biochemistry
42
2072-2080
2003
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Neve
Tissue distribution, intracell ...
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Falk
Constitutive overexpression of ...
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Garcia
Inhibition of p-hydroxyphenylp ...
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Crystal structure of Pseudomon ...
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4-Hydroxyphenylpyruvate dioxyg ...
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4-Hydroxyphenylpyruvate dioxyg ...
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Alternate substrates and inhib ...
Pseudomonas sp., Pseudomonas sp. P.J. 874
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4
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395374
Evans
A nonenzymic oxygen uptake and ...
Sus scrofa
Experientia
39
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1983
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30
1
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3
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Inhibition of 4-hydroxyphenylp ...
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11
-
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3
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1
3
1
1
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1
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Muehl
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4-Hydroxyphenylpyruvate dioxyg ...
Synechococcus elongatus PCC 7942
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1
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1
1
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3
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3
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1
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1
1
1
2
1
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3
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3
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1
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Lindstedt
Purification and some properti ...
Pseudomonas sp., Pseudomonas sp. P.J. 874
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2
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1
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2
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11
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1
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2
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1
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1
1
4
1
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-
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1
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395385
Nakai
Studies on a possible reaction ...
Bos taurus
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67
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1975
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1
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Wada
Purification and properties of ...
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2
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395388
Abbott
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alpha-Ketoglutarate-coupled di ...
Bos taurus, Canis lupus familiaris, Cavia porcellus, Didelphidae, Frog, Gallus gallus, Homo sapiens, Oncorhynchus mykiss, Oryctolagus cuniculus, Platyrrhini, Rattus norvegicus, Sus scrofa
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23
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12
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395389
Fellman
Assay, properties and tissue d ...
Didelphidae, Oncorhynchus mykiss, Platyrrhini, Rattus norvegicus
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284
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1972
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1
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6
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1
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9
1
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6
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1
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La Du
The tyrosine oxidation system ...
Canis lupus familiaris
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1
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