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Literature summary for 1.13.11.27 extracted from
- Scavenging properties of neutrophil 4-hydroxyphenylpyruvate dioxygenase are based on a hypothesis that does not stand up to scrutiny (2014), Biomed. Pharmacother., 68, 1045-1048 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylpyruvate + O2 | Homo sapiens | - |
homogentisate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P32754 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | - |
Homo sapiens | - |
| U-937 cell | a monoblast-like human histiocytic lymphoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxyphenylpyruvate + O2 | - |
Homo sapiens | homogentisate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HPD | - |
Homo sapiens |
| HPPD | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | neutrophil preparations from a patient with tyrosinemia type III, with inherited deficiency of 4-hydroxyphenylpyruvate dioxygenase (HPPD), exhibit a far higher NO release than controls, when NO is estimated in terms of nitrite content in the suspending media. L-tyrosine increases nitrite release and accumulation in suspending media of U-937 cells, a human monoblast-like lymphoma cell line which displays many characteristics of macrophages, including the expression of inducible and endothelial nitric oxide synthases. The increase of nitrite release by patient's neutrophils might be related to the presence of high L-tyrosine concentrations in the blood samples rather than to HPPD deficiency of in these cells | Homo sapiens |
| metabolism | hydroxyphenylpyruvate dioxygenase catalyzes the second step in the pathway of L-tyrosine catabolism, the conversion of 4-hydroxyphenylpyruvate to homogentisate | Homo sapiens |
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Release 2023.1 (January 2023)
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