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Literature summary for 1.13.11.27 extracted from

  • Garcia, P.; Moreau, A.; Ierich, J.; Vig, A.; Higa, A.; Oliveira, G.; Abdalla, F.; Hausen, M.; Leite, F.
    A nanobiosensor based on 4-hydroxyphenylpyruvate dioxygenase enzyme for mesotrione detection (2015), IEEE Sens. J., 15, 2106-2113 .
No PubMed abstract available

Application

Application Comment Organism
diagnostics the enzyme can be used for enzyme-based sensors for monitoring herbicides used in agriculture, i.e. mesotrione. Compared to the standard sensors, biosensors have assorted advantages, such as practicality, quick response, low cost, and high sensitivity. A nanobiosensor is developed based on HPPD for mesotrione detection Homo sapiens
environmental protection the enzyme can be used for enzyme-based sensors for monitoring herbicides used in agriculture, i.e. mesotrione. Compared to the standard sensors, biosensors have assorted advantages, such as practicality, quick response, low cost, and high sensitivity. A nanobiosensor is developed based on HPPD for mesotrione detection Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a nanobiosensor based on HPPD for mesotrione detection. The atomic force microscope tip functionalization with HPPD immobilized in self-assembled monolayers is confirmed by fluorescence microscopy and atomic force spectroscopy. The cross-linker N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride is responsible for properly preserving the enzyme on the tip Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
mesotrione molecular docking and molecular dynamics simulation estimate the interacting regions of HPPD with mesotrione using structure PDB ID 3ISQ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylpyruvate + O2 Homo sapiens
-
homogentisate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P32754
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation pure enzyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylpyruvate + O2
-
Homo sapiens homogentisate + CO2
-
?

Synonyms

Synonyms Comment Organism
HPPD
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000068 0.0236 mesotrione dependent on the system used, overview. pH and temperature not specified in the publication Homo sapiens