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Literature summary for 1.13.11.31 extracted from

  • Collins, J.F.; Hu, Z.; Ranganathan, P.N.; Feng, D.; Garrick, L.M.; Garrick, M.D.; Browne, R.W.
    Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators (2008), Am. J. Physiol. Gastrointest. Liver Physiol., 294, G948-G962.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene alox15, expression analysis and genotyping of wild-type and iron-deficient mutant rats, gene alox15 doesnot respond to iron, transcription regulation via cytokines and growth factors, overview Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient Belgrade rats, the lipids are almoste absent in wild-type rats, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ dependent on Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Rattus norvegicus the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient rats, the lipids are almoste absent in wild-type rats, overview (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q02759 wild-type Sprague-Dawley rats and iron-deficient Belgrade rats, three isozymes: platelet, leukocyte, and epidermis isozyme, Alox15 is a leukocyte-type isozyme
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Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
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 Rattus norvegicus
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epidermis
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 Rattus norvegicus
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intestine
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 Rattus norvegicus
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leukocyte Alox15 Rattus norvegicus
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liver
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 Rattus norvegicus
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additional information the leukocyte-type isozyme is widely distributed in cell types, while the epidermis-type and the platelet-type isozymes are more limited Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
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 Rattus norvegicus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate ?
arachidonate + O2 the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient rats, the lipids are almoste absent in wild-type rats, overview Rattus norvegicus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate ?
additional information intestinal leukocyte-type isozyme Alox15 shows poor or no 15-lipoxygenase activity, EC 1.13.11.33 Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
12-lipoxygenase
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 Rattus norvegicus
Alox15
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 Rattus norvegicus