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Literature summary for 1.13.11.31 extracted from
- Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases (2007), Biochim. Biophys. Acta, 1770, 1062-1070.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics with lysophospholipid substrates | Sus scrofa | |
| 0.0151 | - |
1-linoleoyl lysophosphatidylcholine | pH 7.5, 25°C | Sus scrofa |  |
| 0.0312 | - |
linoleic acid | pH 7.5, 25°C | Sus scrofa | |
| 0.0355 | - |
1-linoleoyl lysophosphatidic acid | pH 7.5, 25°C | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | Sus scrofa | - |
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Sus scrofa | - |
| leukocyte | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 51.8 | - |
commercial preparation | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-linoleoyl lysophosphatidic acid + O2 | i.e. linoleoyl-lysoPA | Sus scrofa | (S)-hydroperoxy 1-linoleoyl lysophosphatidic acid | major product | ? | |
| 1-linoleoyl lysophosphatidylcholine + O2 | i.e. linoleoyl-lysoPC | Sus scrofa | (S)-hydroperoxy 1-linoleoyl lysophosphatidylcholine | major product | ? | |
| arachidonate + O2 | - |
Sus scrofa | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | - |
? | |
| linoleic acid + O2 | - |
Sus scrofa | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? | |
| additional information | stereo-selectivity in LOX-catalyzed oxygenation of lysophospholipids, overview | Sus scrofa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 12-lipoxygenase | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Sus scrofa |
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Release 2023.1 (January 2023)
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