Literature summary for 1.13.11.31 extracted from

Nagasawa, K.; Kakuda, T.; Higashi, Y.; Fujimoto, S.
Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons (2007), Neurosci. Lett., 429, 120-125.

Search for more literature for 1.13.11.31

Inhibitors

Inhibitors	Comment	Organism	Structure
AA861	a 12-LOX inhibitor	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
arachidonate + O2	Rattus norvegicus	poly(ADP-ribose) polymerase activation of 12-LOX, but not NADPH oxidase, following zinc release, might play an important role in reactive oxygen species generation and decrease of viability in glucose-reload-treated neurons, overview	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	primary cortical culture	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Rattus norvegicus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate	-	?
arachidonate + O2	poly(ADP-ribose) polymerase activation of 12-LOX, but not NADPH oxidase, following zinc release, might play an important role in reactive oxygen species generation and decrease of viability in glucose-reload-treated neurons, overview	Rattus norvegicus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
12-lipoxygenase	-	Rattus norvegicus
12-LOX	-	Rattus norvegicus

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Release 2023.1 (January 2023)