Literature summary for 1.13.11.31 extracted from

Zhang, C.; Ma, C.; Yao, H.; Zhang, L.; Yu, X.; Liu, Y.; Shen, T.; Zhang, L.; Zhang, F.; Chen, X.; Zhu, D.
12-lipoxygenase and 12-hydroxyeicosatetraenoic acid regulate hypoxic angiogenesis and survival of pulmonary artery endothelial cells via PI3K/Akt pathway (2018), Am. J. Physiol. Lung Cell. Mol. Physiol., 314, L606-L616 .

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Application

Application	Comment	Organism
medicine	hypoxia increases the formation of endogenous 12-hydroxyeicosatetraenoic acid through stimulation of 12-lipoxygenase. 12-hydroxyeicosatetraenoic acid promotes endothelial cell migration and tube formation, whereas it inhibits the serum deprivation-induced apoptotic responses under hypoxia. The regulatory effects of 12-lipoxygenase/12-hydroxyeicosatetraenoic acid on pulmonary artery endothelial cells, at least in part, depend on phosphatidylinositol 3-kinase (PI3K)/Akt signaling activatio	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q2KMM4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelium	pulmonary artery endothelial cell	Rattus norvegicus	-
lung	-	Rattus norvegicus	-
pulmonary artery	pulmonary artery endothelial cell	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
Alox12b	-	Rattus norvegicus

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Release 2023.1 (January 2023)