Literature summary for 1.13.11.31 extracted from

Leiria, L.O.; Wang, C.H.; Lynes, M.D.; Yang, K.; Shamsi, F.; Sato, M.; Sugimoto, S.; Chen, E.Y.; Bussberg, V.; Narain, N.R.; Sansbury, B.E.; Darcy, J.; Huang, T.L.; Kodani, S.D.; Sakaguchi, M.; Rocha, A.L.; Schulz, T.J.; Bartelt, A.; Hotamisligil, G.S.; Hirshman, M.F.; van Leyen, K.; Goodyear, L.J.; Blueher, M.
12-Lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat (2019), Cell Metab., 30, 768-783.e7 .

Application

Application	Comment	Organism
medicine	humans acutely treated with specific beta3-adrenergic agonist mirabegron display elevated levels of 12-LOX metabolites in the circulation, and significantly higher levels of 12-hydroxyeicosapentaenoic acid and 14-hydroxydocosahexaenoic acid are found in the media of brown adipocytes treated with the beta3-adrenergic agonist CL316,243 for 4 hours	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	P55249	-	-

General Information	Comment	Organism
physiological function	cold and beta3-adrenergic stimulation can promote the biosynthesis and release of 12-LOX metabolites from brown adipose tissue. 12-LOX ablation in brown adipocytes impaires glucose uptake and metabolism, resulting in blunted adaptation to the cold in vivo. The cold-induced 12-LOX product 12-hydroxyeicosapentaenoic acid is a batokine that improves glucose metabolism by promoting glucose uptake into adipocytes and skeletal muscle through activation of an insulin-like intracellular signaling pathway	Mus musculus

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Release 2023.1 (January 2023)