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Literature summary for 1.13.11.31 extracted from

  • Sarsour, E.H.; Son, J.M.; Kalen, A.L.; Xiao, W.; Du, J.; Alexander, M.S.; OLeary, B.R.; Cullen, J.J.; Goswami, P.C.
    Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer (2020), J. Biol. Chem., 295, 6946-6957 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine older normal human fibroblasts (NHFs) have significantly increased arachidonic acid 12-lipoxygenase (ALOX12) expression and elevated levels of its mitogenic metabolite, 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-(S)-HETE) compared with their younger counterparts. In cocultures with older rather than with younger NHFs, pancreatic ductal adenocarcinoma cells exhibit increases in mitogen-activated protein kinase signaling and cellular metabolism, as well as a lower oxidation state that correlates with their enhanced proliferation and resistance to radiation therapy. Expression of ALOX12 is significantly lower in pancreatic ductal adenocarcinoma cell lines and tumor biopsies Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P18054
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-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
ALOX12
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 Homo sapiens