Literature summary for 1.13.11.33 extracted from

Sadik, C.D.; Sies, H.; Schewe, T.
Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action (2003), Biochem. Pharmacol., 65, 773-781.

Search for more literature for 1.13.11.33

Inhibitors

Inhibitors	Comment	Organism
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one	IC50: 0.05 mM	Glycine max
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one	IC50: 0.015 mM	Oryctolagus cuniculus
apigenin	IC50: 0.5 mM	Glycine max
apigenin	IC50: 0.18 mM	Oryctolagus cuniculus
baicalein	IC50: 0.035 mM	Glycine max
baicalein	IC50: 0.001 mM	Oryctolagus cuniculus
chrysin	IC50: 1 mM	Oryctolagus cuniculus
daidzein	IC50: 0.25 mM	Glycine max
daidzein	IC50: 0.43 mM	Oryctolagus cuniculus
epicatechin	IC50: 0.06 mM	Oryctolagus cuniculus
fisetin	IC50: 0.0035 mM	Glycine max
fisetin	IC50: 0.0018 mM	Oryctolagus cuniculus
flavone	IC50: 0.7 mM	Glycine max
flavone	IC50: 0.32 mM	Oryctolagus cuniculus
galangin	IC50: 0.2 mM	Glycine max
galangin	IC50: 0.045 mM	Oryctolagus cuniculus
genistein	IC50: 1 mM	Glycine max
genistein	IC50: 0.018 mM	Oryctolagus cuniculus
hesperetin	IC50: 0.09 mM	Oryctolagus cuniculus
luteolin	IC50: 0.003 mM	Glycine max
luteolin	IC50: 0.0006 mM	Oryctolagus cuniculus
morin	IC50: 0.018 mM	Glycine max
morin	IC50: 0.006 mM	Oryctolagus cuniculus
myricetin	IC50: 0.006 mM	Glycine max
myricetin	IC50: 0.018 mM	Oryctolagus cuniculus
naringenin	IC50: 0.25 mM	Oryctolagus cuniculus
quercetin	IC50: 0.0045 mM	Glycine max
quercetin	IC50: 0.004 mM	Oryctolagus cuniculus
rutin	IC50: 1 mM	Oryctolagus cuniculus
taxifolin	IC50: 1 mM	Glycine max
taxifolin	IC50: 0.025 mM	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Glycine max	-	-	-
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
reticulocyte	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
linoleic acid + O2	-	Oryctolagus cuniculus	?	-	?
linoleic acid + O2	-	Glycine max	?	-	?

Synonyms

Synonyms	Comment	Organism
15-lipoxygenase-1	-	Glycine max
lipoxygenase L-1	-	Glycine max
reticulocyte 15-lipoxygenase-1	-	Oryctolagus cuniculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0006	-	IC50: 0.0006 mM	Oryctolagus cuniculus	ABT-384
0.001	-	IC50: 0.001 mM	Oryctolagus cuniculus	baicalein
0.0018	-	IC50: 0.0018 mM	Oryctolagus cuniculus	fisetin
0.003	-	IC50: 0.003 mM	Glycine max	ABT-384
0.0035	-	IC50: 0.0035 mM	Glycine max	fisetin
0.004	-	IC50: 0.004 mM	Oryctolagus cuniculus	quercetin
0.0045	-	IC50: 0.0045 mM	Glycine max	quercetin
0.006	-	IC50: 0.006 mM	Glycine max	myricetin
0.006	-	IC50: 0.006 mM	Oryctolagus cuniculus	morin
0.015	-	IC50: 0.015 mM	Oryctolagus cuniculus	3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
0.018	-	IC50: 0.018 mM	Oryctolagus cuniculus	genistein
0.018	-	IC50: 0.018 mM	Oryctolagus cuniculus	myricetin
0.018	-	IC50: 0.018 mM	Glycine max	morin
0.025	-	IC50: 0.025 mM	Oryctolagus cuniculus	taxifolin
0.035	-	IC50: 0.035 mM	Glycine max	baicalein
0.045	-	IC50: 0.045 mM	Oryctolagus cuniculus	galangin
0.05	-	IC50: 0.05 mM	Glycine max	3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
0.06	-	IC50: 0.06 mM	Oryctolagus cuniculus	epicatechin
0.09	-	IC50: 0.09 mM	Oryctolagus cuniculus	hesperetin
0.18	-	IC50: 0.18 mM	Oryctolagus cuniculus	apigenin
0.2	-	IC50: 0.2 mM	Glycine max	galangin
0.25	-	IC50: 0.25 mM	Oryctolagus cuniculus	naringenin
0.25	-	IC50: 0.25 mM	Glycine max	daidzein
0.32	-	IC50: 0.32 mM	Oryctolagus cuniculus	flavone
0.43	-	IC50: 0.43 mM	Oryctolagus cuniculus	daidzein
0.5	-	IC50: 0.5 mM	Glycine max	apigenin
0.7	-	IC50: 0.7 mM	Glycine max	flavone
1	-	IC50: 1 mM	Glycine max	genistein
1	-	IC50: 1 mM	Oryctolagus cuniculus	rutin
1	-	IC50: 1 mM	Oryctolagus cuniculus	chrysin
1	-	IC50: 1 mM	Glycine max	taxifolin