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Literature summary for 1.13.11.33 extracted from

  • Deschamps, J.D.; Kenyon, V.A.; Holman, T.R.
    Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases (2006), Bioorg. Med. Chem., 14, 4295-4301.
    View publication on PubMed
Search for more literature for 1.13.11.33

Inhibitors

Inhibitors Comment Organism Structure
apigenin IC50: 0.0034 mM without Triton X-100, IC50: 0.0003 mM in the presence of 0.01% Triton X-100 Homo sapiens
baicalein potent inhibitor, IC50: 0.0016 mM without Triton X-100, IC50: 0.038 mM in the presence of 0.01% Triton X-100 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
15-hLO-1
-
 Homo sapiens
15-lipoxygenase-1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00018
-
 baicalein
-
 Homo sapiens
0.0011
-
 baicalein in the presence of 0.01% Triton X-100 Homo sapiens
0.002
-
 apigenin
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0003 100 IC50: 0.0034 mM without Triton X-100, IC50: 0.0003 mM in the presence of 0.01% Triton X-100 Homo sapiens apigenin
0.038 100 potent inhibitor, IC50: 0.0016 mM without Triton X-100, IC50: 0.038 mM in the presence of 0.01% Triton X-100 Homo sapiens baicalein