Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.33 extracted from

  • Tang, D.G.; Bhatia, B.; Tang, S.; Schneider-Broussard, R.
    15-Lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size) (2007), Prostaglandins Other Lipid Mediat., 82, 135-146.
    View publication on PubMed
Search for more literature for 1.13.11.33

Activating Compound

Activating Compound Comment Organism Structure
additional information 15-LOX2 in NHP cells is positively regulated by Sp1, the enzyme is induced in cell senescence Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
15-LOX2 has at least six alternatively spliced isoforms Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information 15-LOX2 in NHP cells is negatively regulated by Sp3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell border
-
 Homo sapiens
-
-
cytoplasm
-
 Homo sapiens 5737
-
cytoskeleton
-
 Homo sapiens 5856
-
nucleus
-
 Homo sapiens 5634
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3, but 15-LOX2 expression in NHP cells is not directly regulated by androgen/androgen receptor, overview (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
additional information Homo sapiens 15-LOX2 is a functional tumor suppressor that regulates prostate epithelial cell differentiation, senescence, and growth size, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15296
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
-
additional information 15-LOX2 expression is decreased or lost in high-grade prostate intraepithelial neoplasia and prostate cancer PCa cells Homo sapiens
-
prostate epithelial cells, 15-LOX2 has multiple alternatively spliced isoforms and is a negative cell-cycle regulator in normal prostate epithelial cells, 15-LOX2 is positively regulated by Sp1 and negatively regulated by Sp3, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate is further metabolized to (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate, i.e. 15(S)-HETE ?
arachidonate + O2 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3, but 15-LOX2 expression in NHP cells is not directly regulated by androgen/androgen receptor, overview Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
additional information 15-LOX2 is a functional tumor suppressor that regulates prostate epithelial cell differentiation, senescence, and growth size, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
15-lipoxygenase 2
-
 Homo sapiens
15-LOX2
-
 Homo sapiens