Literature summary for 1.13.11.33 extracted from

Liu, C.; Xu, D.; Liu, L.; Schain, F.; Brunnstroem, A.; Bjoerkholm, M.; Claesson, H.E.; Sjoeberg, J.
15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells (2009), Am. J. Physiol. Lung Cell Mol. Physiol., 297, L196-L203.

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Cloned(Commentary)

Cloned (Comment)	Organism
15-LOX-1 cDNA fragment without 3'-UTR inserted into pLP-IRESneo, overexpression of 15-LOX-1 in A549 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
5,8,11,14-Eicosatetraynoic acid	-	Homo sapiens
nordihydroguaiaretic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
dendritic cell	-	Homo sapiens	-
epithelial cell	airway	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
15-lipoxygenase-1	-	Homo sapiens
15-LOX-1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	normal human airway epithelial cells treated with interleukin-4 express higher levels of 15-LOX-1 than transfected A549 cells	up

General Information

General Information	Comment	Organism
malfunction	when 15-LOX-1 activity is knocked down by siRNA, the induction of MIP-1alpha, RANTES, and IP-10 is significantly attenuated	Homo sapiens
physiological function	15-LOX-1 induces chemokine expression in A549 cells. Increased expression and activity of 15-LOX-1 in lung epithelial cells is a proinflammatory event in the pathogenesis of asthma and other inflammatory lung disorders. 15-LOX-1 overexpression results in upregulation of MIP-1alpha, MIP11beta, and RANTES, in increased migration of immature dendritic cells and of activated T cells and increases chemotaxis of mast cells. 15-LOX-1 ectopic expression upregulates NF-kappaB activity	Homo sapiens

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Release 2023.1 (January 2023)