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Literature summary for 1.13.11.33 extracted from

  • Zhao, J.; Maskrey, B.; Balzar, S.; Chibana, K.; Mustovich, A.; Hu, H.; Trudeau, J.B.; ODonnell, V.; Wenzel, S.E.
    Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells (2009), Am. J. Respir. Crit. Care Med., 179, 782-790.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
drug development trials of 15LO1 pathway inhibitors in asthma may be a promising treatment strategy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6,11-dihydro[1]benzothiopyrano[4,3-b]indole PD146176 Homo sapiens
siRNA
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell in airway epithelial cells, 15LO1 expression increases with asthma severity and correlates with MUC5AC expression Homo sapiens
-

Synonyms

Synonyms Comment Organism
15-lipoxygenase 1
-
 Homo sapiens
15LO1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interleukin-13 induces 15LO1 expression and production of intracellular 15-hydroxyeicosatetraenoic acid conjugated to phosphotidylethanolamine in vitro. 15-hydroxyeicosatetraenoic acid enhances interleukin-13 induced MUC5AC expression in vitro up

General Information

General Information Comment Organism
physiological function high levels of 15LO1 activity can contribute to the increases of MUC5AC observed in asthma Homo sapiens