Cloned (Comment) | Organism |
---|---|
transgenic mice overexpressing 15-LO-1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
skeletal muscle | - |
Oryctolagus cuniculus | - |
vasculature | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase-1 | - |
Homo sapiens |
15-lipoxygenase-1 | - |
Oryctolagus cuniculus |
15-LO-1 | - |
Homo sapiens |
15-LO-1 | - |
Oryctolagus cuniculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | induction by interleukin-4 and interleukin-13 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | 15-LO-1 plays active roles in vascular remodeling, the progression of atherosclerosis and angiogenesis. The PC-3 prostate cancer cell line, which overexpresses 15-LO-1, secretes high levels of vascular endothelial growth factor and enhances tumor growth and angiogenesis as compared with the parental PC-3 cell lines. Angiogenesis and tumor formation is inhibited in transgenic mice overexpressing 15-LO-1 in endothelial cells under the control of preproendothelin promoter. Potential role of 15-LO-1 in regulating endothelium-derived NO, the expression level and activity of 15-LO-1 in endothelial cells may act as a potential NO barometer by modulating the level of eNOS enzyme and bioactive free NO in endothelial cells. 15-LO-1 in human endothelial cells can inhibit angiogenesis and vascular permeability by removing free NO, and its activity can in turn be modulated by the cytoplasmic NO level | Homo sapiens |
physiological function | is a regulator of angiogenesis, antiangiogenic action in skeletal muscle system. 15-LO-1 significantly decreases all angiogenic effects induced by vascular endothelial growth factor-A and placental growth factor, including capillary perfusion, vascular permeability, vasodilatation, and the increase in capillary number | Oryctolagus cuniculus |