Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.33 extracted from

  • Tirapegui, C.; Acevedo-Fuentes, W.; Dahech, P.; Torrent, C.; Barrias, P.; Rojas-Poblete, M.; Mascayano, C.
    Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase (2017), Bioorg. Med. Chem. Lett., 27, 1649-1653 .
    View publication on PubMed
Search for more literature for 1.13.11.33

Inhibitors

Inhibitors Comment Organism Structure
4-(2-benzoylhydrazinyl)benzene-1-sulfonamide 10% inhibition Homo sapiens
4-[(E)-benzoyldiazenyl]benzene-1-sulfonamide
-
 Homo sapiens
4-[(E)-benzoyldiazenyl]benzonitrile 80% inhibition, competitive Homo sapiens
additional information synthesis and evaluation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase, overview Homo sapiens
N'-(4-bromophenyl)benzohydrazide 28% inhibition Homo sapiens
N'-(4-cyanophenyl)benzohydrazide 9% inhibition Homo sapiens
N'-(4-methoxyphenyl)benzohydrazide 73% inhibition Homo sapiens
N'-(4-methylphenyl)benzohydrazide 93% inhibition, competitive Homo sapiens
N'-(4-nitrophenyl)benzohydrazide 17% inhibition Homo sapiens
N'-phenylbenzohydrazide 33% inhibition Homo sapiens
phenyl[(E)-phenyldiazenyl]methanone 87% inhibition Homo sapiens
[(E)-(4-bromophenyl)diazenyl](phenyl)methanone 44% inhibition Homo sapiens
[(E)-(4-methoxyphenyl)diazenyl](phenyl)methanone 19% inhibition Homo sapiens
[(E)-(4-methylphenyl)diazenyl](phenyl)methanone 44% inhibition Homo sapiens
[(E)-(4-nitrophenyl)diazenyl](phenyl)methanone 34% inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens best substrate (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16050
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2 best substrate Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
15-lipoxygenase
-
 Homo sapiens
15-LOX
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00081
-
 N'-(4-methylphenyl)benzohydrazide pH and temperature not specified in the publication Homo sapiens
0.00398
-
 4-[(E)-benzoyldiazenyl]benzonitrile pH and temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00535
-
 pH and temperature not specified in the publication Homo sapiens N'-(4-methylphenyl)benzohydrazide
0.00697
-
 pH and temperature not specified in the publication Homo sapiens phenyl[(E)-phenyldiazenyl]methanone
0.00978
-
 pH and temperature not specified in the publication Homo sapiens 4-[(E)-benzoyldiazenyl]benzonitrile