Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | stimulates | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,6-Methano-leukotriene A4 | - |
Mus musculus | |
8,11,13-cis-icosatrienoic acid | - |
Mus musculus | |
AA861 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | 55000 | gel filtration | Mus musculus |
75000 | - |
x * 75000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | bone marrow-derived mast cell line PB-3c | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate + O2 | - |
Mus musculus | leukotriene A4 | - |
? | |
arachidonate + O2 | i.e. 5,8,11,14-eicosatetraenoic acid | Mus musculus | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? | |
additional information | arachidonate 5-lipoxygenase and leukotriene A5 synthase are identical | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 75000, SDS-PAGE | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
8,11,13-cis-icosatrienoic acid | - |
Mus musculus |