Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adenosine | 58% of the activation with ATP | Homo sapiens | |
ADP | 74% of the activation with ATP | Homo sapiens | |
ADP-beta-S | 82% of the activation with ATP | Homo sapiens | |
AMP | 68% of the activation with ATP | Homo sapiens | |
AMP-4-nitrophenylphosphate | 77% of the activation with ATP | Homo sapiens | |
ATP-alphaS | 118% of the activation with ATP | Homo sapiens | |
ATP-gammaS | 80% of the activation with ATP | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-670,630 | IC50: 0.0004 mM | Homo sapiens | |
L-689,065 | IC50: 0.0003 mM | Homo sapiens | |
L-697,198 | IC50: 0.00002 mM | Homo sapiens | |
L-702,590 | - |
Homo sapiens | |
L-702,701 | IC50: 0.0015 mM | Homo sapiens | |
L705,302 | IC50: 0.00002 mM | Homo sapiens | |
N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea | IC50: 0.0001 mM | Homo sapiens | |
ZD 2138 | i.e. CAS: 140841-32-3, IC50: 0.0003 mM | Homo sapiens | |
zileuton | IC50: 0.01 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | i.e. 5,8,11,14-eicosatetraenoic acid | Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
IC50: 0.00002 mM | Homo sapiens | L-697,198 | |
0.00002 | - |
IC50: 0.00002 mM | Homo sapiens | L705,302 | |
0.0001 | - |
IC50: 0.0001 mM | Homo sapiens | N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea | |
0.0003 | - |
IC50: 0.0003 mM | Homo sapiens | L-689,065 | |
0.0003 | - |
i.e. CAS: 140841-32-3, IC50: 0.0003 mM | Homo sapiens | ZD 2138 | |
0.0004 | - |
IC50: 0.0004 mM | Homo sapiens | L-670,630 | |
0.0015 | - |
IC50: 0.0015 mM | Homo sapiens | L-702,701 | |
0.01 | - |
IC50: 0.01 mM | Homo sapiens | zileuton |