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Literature summary for 1.13.11.34 extracted from

  • Wetterholm, A.; Macchia, L.; Haeggstrom, J.Z.
    Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes (1994), Arch. Biochem. Biophys., 311, 253-271.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
additional information zinc inhibits leukotriene B4 formation due to a direct or indirect inhibitory effect on 5-lipoxygenase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
leukocyte polymorphonuclear Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
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