Inhibitors | Comment | Organism | Structure |
---|---|---|---|
celecoxib | - |
Homo sapiens | |
CGP28238 | - |
Homo sapiens | |
Cox-189 | - |
Homo sapiens | |
diclofenac | - |
Homo sapiens | |
eltenac | - |
Homo sapiens | |
etoricoxib | - |
Homo sapiens | |
meloxicam | - |
Homo sapiens | |
MK-886 | - |
Homo sapiens | |
ML-3000 | i.e. licofelone, ML-3000 has no effect on 5-LOX product synthesis in whole-blood assay, inhibition of COX pathways does not increase the transformation of arachidonic acid by the 5-LOX pathway | Homo sapiens | |
nimesulide | - |
Homo sapiens | |
parecoxib | - |
Homo sapiens | |
rofecoxib | - |
Homo sapiens | |
SC-560 | - |
Homo sapiens | |
valdecoxib | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Homo sapiens | - |
leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 | ? | |
arachidonic acid + O2 | Homo sapiens | - |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
additional information | Homo sapiens | inhibition of COX pathways does not increase the transformation of arachidonic acid by the 5-LOX pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | polymorphonuclear | Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | - |
? | |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 | ? | |
arachidonic acid + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
additional information | inhibition of COX pathways does not increase the transformation of arachidonic acid by the 5-LOX pathway | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Homo sapiens |
5-LOX | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
inhibitory activity in polymorphonuclear leukocytes, overview | Homo sapiens | additional information | |
0.0032 | - |
37°C, whole blood assay | Homo sapiens | MK-886 | |
0.0195 | - |
37°C, whole blood assay | Homo sapiens | celecoxib | |
0.1 | - |
above, 37°C, whole blood assay | Homo sapiens | ML-3000 |