Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.34 extracted from

  • Strid, T.; Svartz, J.; Franck, N.; Hallin, E.; Ingelsson, B.; Soederstroem, M.; Hammarstroem, S.
    Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein (2009), Biochem. Biophys. Res. Commun., 381, 518-522.
    View publication on PubMed
Search for more literature for 1.13.11.34

Cloned(Commentary)

Cloned (Comment) Organism
5-lipoxygenase cDNA cloned into EGFP fusion protein vector (pEGFP-h5-LO) and expressed in HEK293/T or COS-7 cells, or into a pUC13 vector, full length 5-lipoxygenase cDNA subcloned into pGEX and pcDNA3, expressed in Escherichia coli Y1090 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus in stimulated HEK293/T and COS-7 cells the activated 5-lipoxygenase appears mainly at the nuclear envelope Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ upon stimulation with calcium ionophore, GFP-5-lipoxygenase translocates to the nuclear envelope allowing it to interact with 5-lipoxygenase activating protein (FLAP) and leukotriene C4 synthase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
 Homo sapiens
5-LO
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function 5-lipoxygenase/5-lipoxygenase activating protein interaction, which may serve as a feed-back control point for leukotriene C4 biosynthesis Homo sapiens