Literature summary for 1.13.11.34 extracted from

Borges, C.L.; Cecchini, R.; Tatakihara, V.L.; Malvezi, A.D.; Yamada-Ogatta, S.F.; Rizzo, L.V.; Pinge-Filho, P.
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas disease (2009), Immunol. Lett., 123, 38-45.

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Inhibitors

Inhibitors	Comment	Organism	Structure
nordihydroguaiaretic acid	reduces oxidative damage of erythrocytes in C57BL/6 Trypanosoma cruzi-infected mice but not in C57BL/6 iNOS-/- infected mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6, 129Sv mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
5-lipoxygenase	-	Mus musculus
5-LO	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	5-LO-/- infected with Trypanosoma cruzi, are more susceptible than C57BL/6 and wild-type 129Sv, showing higher parasitemia and mortality	Mus musculus
physiological function	5-lipoxygenase products may not only play a major role in controlling heart tissue parasitism, i.e., host resistance to acute infection with Trypanosoma cruzi in vivo, but in the event of an infection also play an important part in erythrocyte oxidative stress, an NO-dependent effect. 5-lipoxygenase metabolites increase lipid peroxidation levels in erythrocytes during the early phase of murine Trypanosoma cruzi infection, but do not participate in the development of anemia, thrombocytopenia or leukopenia in Trypanosoma cruzi-infected mice	Mus musculus

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Release 2023.1 (January 2023)