Literature summary for 1.13.11.34 extracted from

Karg, E.M.; Luderer, S.; Pergola, C.; Buehring, U.; Rossi, A.; Northoff, H.; Sautebin, L.; Troschuetz, R.; Werz, O.
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase (2009), J. Med. Chem., 52, 3474-3483.

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Application

Application	Comment	Organism
drug development	due to their high potency against 5-lipoxygenase and the marked efficacy in biological systems, benzo[g]indole-3-carboxylates may have potential as anti-inflammatory therapeutics	Homo sapiens
drug development	due to their high potency against 5-lipoxygenase and the marked efficacy in biological systems, benzo[g]indole-3-carboxylates may have potential as anti-inflammatory therapeutics	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
benzyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
benzyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 1-benzyl-2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	prevents leukotriene B4 production in pleural exudates of carrageenan-treated rats, associated with reduced severity of pleurisy. Significantly reduces the inflammatory reaction measured as exudate volume (77%), inflammatory cell numbers (40%), and leukotriene B4 levels (49%) in the pleural exudates	Rattus norvegicus
ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-pyrrolo[2,3-f]quinoline-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorobenzyl)-5-hydroxy-6-phenyl-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorobenzyl)-5-methoxy-1-methyl-1H-benzo[g]-indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorobenzyl)-5-phenyl-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorobenzyl)-7,8-dimethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(3-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-(4-trifluoromethylbenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-[(3-chlorophenyl)-amino]-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 5-benzoyloxy-2-(3-chlorobenzyl)-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 5-hydroxy-2-phenylethyl-1H-indole-3-carboxylate	-	Homo sapiens
ethyl 5-hydroxy-2-phenylpropyl-1H-benzo[g]indole-3-carboxylate	-	Homo sapiens
ethyl 6-biphenyl-4-yl-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-(allylamino)-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-(benzylamino)-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-(diallylamino)-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-[(2-chlorophenyl)amino]-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-[(3-bromophenyl)amino]-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-[(3-chlorophenyl)amino]-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-[(3-chlorophenyl)amino]-5-chloro-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-[(3-fluorophenyl)amino]-1H-indole-3-carboxylate	-	Homo sapiens
methyl 2-[(4-chlorophenyl)amino]-1H-indole-3-carboxylate	-	Homo sapiens
N-(3-phenoxycinnamyl)-acetohydroxamic acid	-	Homo sapiens
zileuton	-	Homo sapiens
zileuton	reduces exudate formation (77%), cell infiltration (41%), and leukotriene B4 exudate levels (66%)	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	stimulation with calcium ionophore	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-
neutrophil	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Homo sapiens	(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
5-lipoxygenase	-	Homo sapiens
5-lipoxygenase	-	Rattus norvegicus
5-LO	-	Homo sapiens
5-LO	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000031	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000038	-	recombinant 5-lipoxygenase	Homo sapiens	N-(3-phenoxycinnamyl)-acetohydroxamic acid
0.000045	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000049	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000067	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000084	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000086	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000095	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000096	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.000097	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00013	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00013	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 5-hydroxy-2-phenylpropyl-1H-benzo[g]indole-3-carboxylate
0.00013	-	recombinant 5-lipoxygenase	Homo sapiens	benzyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00014	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00015	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00015	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00016	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	N-(3-phenoxycinnamyl)-acetohydroxamic acid
0.00017	-	recombinant 5-lipoxygenase	Homo sapiens	benzyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00023	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00025	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-trifluoromethylbenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0003	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-[(3-chlorophenyl)-amino]-5-hydroxy-1H-indole-3-carboxylate
0.00032	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00033	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 6-biphenyl-4-yl-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.00034	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00035	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	benzyl 2-(3-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00044	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 5-hydroxy-2-phenylpropyl-1H-benzo[g]indole-3-carboxylate
0.00045	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00048	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	benzyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00049	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0005	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-fluorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00052	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00052	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00058	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-pyrrolo[2,3-f]quinoline-3-carboxylate
0.0006	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-bromobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00065	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-methoxybenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.00065	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 1-benzyl-2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0007	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.0007	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
0.0008	-	recombinant 5-lipoxygenase	Homo sapiens	zileuton
0.0009	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	zileuton
0.0012	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0012	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0012	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.0012	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-6-phenyl-1H-indole-3-carboxylate
0.0016	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.0017	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.0017	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(2-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.0017	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-trifluoromethylbenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0017	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
0.0018	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 1-benzyl-2-(4-chlorobenzyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.002	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
0.002	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.0021	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(4-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
0.0024	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-[(3-chlorophenyl)-amino]-5-hydroxy-1H-indole-3-carboxylate
0.0028	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-[2-(3-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
0.0028	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0028	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 6-biphenyl-4-yl-(3-chlorobenzyl)-5-hydroxy-1H-indole-3-carboxylate
0.0033	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
0.0034	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-(benzylamino)-1H-indole-3-carboxylate
0.0034	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 5-benzoyloxy-2-(3-chlorobenzyl)-1H-benzo[g]indole-3-carboxylate
0.0035	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-[(3-bromophenyl)amino]-1H-indole-3-carboxylate
0.0035	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-[(3-chlorophenyl)amino]-5-chloro-1H-indole-3-carboxylate
0.0039	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-[2-(4-chlorophenyl)ethyl]-5-hydroxy-1H-indole-3-carboxylate
0.004	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-(benzylamino)-1H-indole-3-carboxylate
0.0043	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-1H-pyrrolo[2,3-f]quinoline-3-carboxylate
0.0048	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-indole-3-carboxylate
0.0055	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-[(3-chlorophenyl)amino]-5-chloro-1H-indole-3-carboxylate
0.0055	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 5-hydroxy-2-phenylethyl-1H-indole-3-carboxylate
0.0057	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-hydroxy-6-phenyl-1H-indole-3-carboxylate
0.0065	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-[(3-chlorophenyl)amino]-1H-indole-3-carboxylate
0.0069	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-(diallylamino)-1H-indole-3-carboxylate
0.007	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorobenzyl)-7,8-dimethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.0072	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-[(4-chlorophenyl)amino]-1H-indole-3-carboxylate
0.0073	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 5-hydroxy-2-phenylethyl-1H-indole-3-carboxylate
0.0079	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-[(3-fluorophenyl)amino]-1H-indole-3-carboxylate
0.0081	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-[(3-chlorophenyl)amino]-1H-indole-3-carboxylate
0.0083	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-[(3-bromophenyl)amino]-1H-indole-3-carboxylate
0.0098	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-[(2-chlorophenyl)amino]-1H-indole-3-carboxylate
0.0098	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-[(4-chlorophenyl)amino]-1H-indole-3-carboxylate
0.01	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 5-benzoyloxy-2-(3-chlorobenzyl)-1H-benzo[g]indole-3-carboxylate
0.01	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorobenzyl)-7,8-dimethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate
0.01	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-methoxy-1-methyl-1H-benzo[g]-indole-3-carboxylate
0.0102	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-[(2-chlorophenyl)amino]-1H-indole-3-carboxylate
0.0125	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-(diallylamino)-1H-indole-3-carboxylate
0.0134	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-[(3-fluorophenyl)amino]-1H-indole-3-carboxylate
0.03	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	methyl 2-(allylamino)-1H-indole-3-carboxylate
0.03	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-methoxy-1-methyl-1H-benzo[g]-indole-3-carboxylate
0.03	-	5-lipoxygenase inhibited in neutrophils	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-phenyl-1H-benzo[g]indole-3-carboxylate
0.03	-	recombinant 5-lipoxygenase	Homo sapiens	methyl 2-(allylamino)-1H-indole-3-carboxylate
0.03	-	recombinant 5-lipoxygenase	Homo sapiens	ethyl 2-(3-chlorobenzyl)-5-phenyl-1H-benzo[g]indole-3-carboxylate