Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.34 extracted from

  • Yu, G.; Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Praveen Rao, P.N.; Das, D.; Velazquez, C.A.; Suresh, M.R.; Knaus, E.E.
    Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity (2010), Bioorg. Med. Chem. Lett., 20, 896-902.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
2-[2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
2-[3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
2-[4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid micromolar 5-LOX inhibitory activity Solanum tuberosum
caffeic acid micromolar 5-LOX inhibitory activity Solanum tuberosum

Organism

Organism UniProt Comment Textmining
Solanum tuberosum
-
-
-

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
Solanum tuberosum
5-LOX
-
Solanum tuberosum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
pH and temperature not specified in the publication Solanum tuberosum 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
0.00037
-
pH and temperature not specified in the publication Solanum tuberosum 3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
0.00037
-
pH and temperature not specified in the publication Solanum tuberosum 2-[3-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
0.002
-
pH and temperature not specified in the publication Solanum tuberosum 2-[2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
0.003
-
pH and temperature not specified in the publication Solanum tuberosum 2-[4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl]propanoic acid
0.00347
-
pH and temperature not specified in the publication Solanum tuberosum 4-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)phenylacetic acid
0.004
-
pH and temperature not specified in the publication Solanum tuberosum caffeic acid