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Literature summary for 1.13.11.34 extracted from

  • Radmark, O.; Samuelsson, B.
    Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer (2010), J. Intern. Med., 268, 5-14.
    View publication on PubMed
Search for more literature for 1.13.11.34

Activating Compound

Activating Compound Comment Organism Structure
coactosin-like protein functions as a 5-LO chaperone Homo sapiens
phosphatidylcholine
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
licofelone dual COX-2?5-LO inhibitor Homo sapiens
sulindac sulfide
-
 Homo sapiens
YS121
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane Homo sapiens 5829
-
nuclear outer membrane when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane Homo sapiens 5640
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ stimulates enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Homo sapiens
-
 leukotriene A4 + H2O
-
 ?
arachidonate + O2 Homo sapiens
-
 (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein cellular 5-LO activity is regulated by both divalent cations and by phosphorylation, mitogen-activatedprotein kinasesandproteinkinase A can phosphorylate 5-LO in the catalytic domain Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Homo sapiens leukotriene A4 + H2O
-
 ?
arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
 Homo sapiens
5-LO
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism 5-LO has a central role in leukotriene biosynthesis Homo sapiens
physiological function several arachidonic acid metabolites formed via the 5-LO pathway (5-HETE, 5-oxo-ETE, leukotriene B4, leukotriene D4) can promote proliferationof cancer cells Homo sapiens