Application | Comment | Organism |
---|---|---|
drug development | human 5-lipoxygenase is a well-validated target for anti-inflammatory therapy. Development of 5-LOX inhibitors with higher activities is highly required | Homo sapiens |
pharmacology | human 5-lipoxygenase is a well-validated target for anti-inflammatory therapy. Development of 5-LOX inhibitors with higher activities is highly required | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-dichlorophenyl 3,5-dinitrobenzoate | - |
Homo sapiens | |
3-((naphthalene-1-yloxy)carbonyl)benzoic acid | - |
Homo sapiens | |
3-(benzyloxycarbonyl)benzoic acid | - |
Homo sapiens | |
3-(naphhthalen-1-ylcarbmoyl)benzoic acid | - |
Homo sapiens | |
3-(phenylcarbamoyl)benzoic acid | - |
Homo sapiens | |
3-propylphenyl 3,5-dinitrobenzoate | - |
Homo sapiens | |
3-tolyl 3,5-dinitrobenzoate | - |
Homo sapiens | |
biphenyl-3-yl 3,5-dinitrobenzoate | - |
Homo sapiens | |
biphenyl-4-yl 3,5-dinitrobenzoate | - |
Homo sapiens | |
additional information | development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors, structure-activity relationship study, overview | Homo sapiens | |
N-(3,4-dimethoxyphenyl)-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-(3-bromobenzyl)-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-(3-bromophenyl)-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-(3-chlorophenyl)-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-(4-methoxyphenyl)-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-(biphenyl-3-yl)-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-(naphthalene-1-yl)-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-3-tolyl-3,5-dinitrobenzamide | - |
Homo sapiens | |
N-phenyl-3,5-dinitrobenzamide | - |
Homo sapiens | |
naphthalen-1-yl 3,5-dinitrobenzoate | JMC-4, identified from virtual inhibitor screening | Homo sapiens | |
naphthalene-1-yl 3-nitrobenzoate | - |
Homo sapiens | |
phenyl 3,5-dinitrobenzoate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | - |
(5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09917 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Homo sapiens |
5-LOX | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
pH 7.4, 37°C | Homo sapiens | 3-tolyl 3,5-dinitrobenzoate | |
0.0027 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-methoxyphenyl)-3,5-dinitrobenzamide | |
0.0065 | - |
pH 7.4, 37°C | Homo sapiens | 3-propylphenyl 3,5-dinitrobenzoate | |
0.0144 | - |
pH 7.4, 37°C | Homo sapiens | N-(3-bromobenzyl)-3,5-dinitrobenzamide | |
0.0152 | - |
pH 7.4, 37°C | Homo sapiens | N-phenyl-3,5-dinitrobenzamide | |
0.0158 | - |
pH 7.4, 37°C | Homo sapiens | phenyl 3,5-dinitrobenzoate | |
0.0246 | - |
pH 7.4, 37°C | Homo sapiens | naphthalene-1-yl 3-nitrobenzoate | |
0.038 | - |
pH 7.4, 37°C | Homo sapiens | biphenyl-3-yl 3,5-dinitrobenzoate | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | 2,3-dichlorophenyl 3,5-dinitrobenzoate | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | biphenyl-4-yl 3,5-dinitrobenzoate | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-(naphthalene-1-yl)-3,5-dinitrobenzamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-3-tolyl-3,5-dinitrobenzamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-(3-chlorophenyl)-3,5-dinitrobenzamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-(3-bromophenyl)-3,5-dinitrobenzamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-(3,4-dimethoxyphenyl)-3,5-dinitrobenzamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-(biphenyl-3-yl)-3,5-dinitrobenzamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | 3-(benzyloxycarbonyl)benzoic acid | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | 3-((naphthalene-1-yloxy)carbonyl)benzoic acid | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | 3-(naphhthalen-1-ylcarbmoyl)benzoic acid | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | 3-(phenylcarbamoyl)benzoic acid |
General Information | Comment | Organism |
---|---|---|
additional information | modeling of the active conformation of human 5-LOX, overview | Homo sapiens |