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Literature summary for 1.13.11.34 extracted from

  • El-Nagar, M.K.S.; Abdu-Allah, H.H.M.; Salem, O.I.A.; Kafafy, A.N.; Farghaly, H.S.M.
    Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes Synthesis, biological evaluation and docking study (2018), Bioorg. Chem., 78, 80-93 .
    View publication on PubMed
Search for more literature for 1.13.11.34

Inhibitors

Inhibitors Comment Organism Structure
5-amino-2-hydroxy-N-(propan-2-yl)benzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2 Solanum tuberosum
5-amino-N-cyclohexyl-2-hydroxybenzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2 Solanum tuberosum
5-amino-N-hexyl-2-hydroxybenzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2 Solanum tuberosum
5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2 Solanum tuberosum
N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2 Solanum tuberosum
N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2 Solanum tuberosum
N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2. Compound shows 114% anti-inflammatory activity relative to reference drug indomethacin at 4 h interval Solanum tuberosum
N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide 5-aminosalicylic acid derivative, additionally inhibits cyclooxygenases Cox-1 and Cox-2 Solanum tuberosum
zileuton
-
 Solanum tuberosum

Organism

Organism UniProt Comment Textmining
Solanum tuberosum
-
-
-

Synonyms

Synonyms Comment Organism
LOX-5
-
 Solanum tuberosum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00341
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum 5-amino-2-hydroxy-N-(propan-2-yl)benzamide
0.00765
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum 5-amino-N-cyclohexyl-2-hydroxybenzamide
0.00796
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-N-(4-methylphenyl)benzamide
0.00841
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum 5-amino-N-hexyl-2-hydroxybenzamide
0.0105
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum N-butyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide
0.0113
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum N-cyclohexyl-5-[(E)-[(2,5-dihydroxyphenyl)methylidene]amino]-2-hydroxybenzamide
0.0119
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum N-hexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide
0.0123
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum N-cyclohexyl-5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxybenzamide
0.0156
-
 pH 7.4, temperature not specified in the publication Solanum tuberosum zileuton