Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Mus musculus | |
lecithin | - |
Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | therapeutic effect of inhibitors of arachidonic acid metabolism on inflammatory skin diseases and epidermal tumors and on tumor development | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-mercaptoethanol | - |
Mus musculus | |
Eicosa-5,8,11,14-tetraynoic acid | - |
Mus musculus | |
glutathione | 50% inhibition | Mus musculus | |
nordihydroguaiaretic acid | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
arachidonic acid | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
microsome | - |
Mus musculus | - |
- |
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 arachidonic acid + 2 O2 | Mus musculus | pathway of epidermal arachidonate oxygenation | 8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
mouse, strain NMR1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | cells of the suprabasal compartment of the epidermis | Mus musculus | - |
skin | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 arachidonic acid + 2 O2 | pathway of epidermal arachidonate oxygenation | Mus musculus | 8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O | - |
? | |
arachidonic acid + O2 | - |
Mus musculus | (8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid | - |
? | |
arachidonic acid + O2 | arachidonic acid, enzyme activity only detectable after in vivo treatment with the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) | Mus musculus | (5Z,8E,11Z,14Z)-8-hydroperoxyicosa-5,8,11,14-tetraenoic acid + (5Z,8E,11Z,14Z)-8-hydroxyicosa-5,8,11,14-tetraenoic acid | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | - |
Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9.5 | - |
Mus musculus |