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Literature summary for 1.13.11.40 extracted from

  • Fuerstenberger, G.; Hagedorn, H.; Jacobi, T.; Besemfelder, E.; Stephan, M.; Lehman, W.D.; Marks, F.
    Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin in vivo (1991), J. Biol. Chem., 266, 15738-15745.
    View publication on PubMed
Search for more literature for 1.13.11.40

Activating Compound

Activating Compound Comment Organism Structure
EDTA
-
 Mus musculus
lecithin
-
 Mus musculus

Application

Application Comment Organism
medicine therapeutic effect of inhibitors of arachidonic acid metabolism on inflammatory skin diseases and epidermal tumors and on tumor development Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
beta-mercaptoethanol
-
 Mus musculus
Eicosa-5,8,11,14-tetraynoic acid
-
 Mus musculus
glutathione 50% inhibition Mus musculus
nordihydroguaiaretic acid
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
 arachidonic acid
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
microsome
-
 Mus musculus
-
-
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 arachidonic acid + 2 O2 Mus musculus pathway of epidermal arachidonate oxygenation 8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse, strain NMR1
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis cells of the suprabasal compartment of the epidermis Mus musculus
-
skin
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 arachidonic acid + 2 O2 pathway of epidermal arachidonate oxygenation Mus musculus 8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O
-
 ?
arachidonic acid + O2
-
 Mus musculus (8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid
-
 ?
arachidonic acid + O2 arachidonic acid, enzyme activity only detectable after in vivo treatment with the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) Mus musculus (5Z,8E,11Z,14Z)-8-hydroperoxyicosa-5,8,11,14-tetraenoic acid + (5Z,8E,11Z,14Z)-8-hydroxyicosa-5,8,11,14-tetraenoic acid
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
6 9.5
-
 Mus musculus