Literature summary for 1.13.11.40 extracted from

Mishra, V.K.; Mishra, S.
Flipped regiospecificity in L434F mutant of 8-lipoxygenase (2020), Phys. Chem. Chem. Phys., 22, 16013-16022 .

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Protein Variants

Protein Variants	Comment	Organism
L434F	mutation alters the regio- and stereospecificity of the final products, with a product ratio of 66 : 34 for 8R- and 12S-hydroperoxide, respectively. In the closed conformation, the phenyl group of Phe434 shields the C8 site of the substrate, preventing access of the oxygen molecule to this site, which leads to a quenching of the 8R-product. Both closed and open conformations of Phe434 allow the oxygen molecule to approach the pro-S face of the C12 site of the substrate, which enhances the propensity of the 12S-hydroperoxide	Plexaura homomalla

Organism

Organism	UniProt	Comment	Textmining
Plexaura homomalla	O16025	bifunctional allene oxide synthase-lipoxygenase protein	-

Synonyms

Synonyms	Comment	Organism
allene oxide synthase-lipoxygenase protein	-	Plexaura homomalla

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Release 2023.1 (January 2023)