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Literature summary for 1.13.11.48 extracted from

  • Frerichs-Deeken, U.; Ranguelova, K.; Kappl, R.; Huettermann, J.; Fetzner, S.
    Dioxygenases without requirement for cofactors and their chemical model reaction: compulsory order ternary complex mechanism of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase involving general base catalysis by histidine 251 and single-electron oxidation of the substrate dianion (2004), Biochemistry, 43, 14485-14499.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Paenarthrobacter ilicis

Protein Variants

Protein Variants Comment Organism
H251A 2258fold lower specific activity than wild-type Paenarthrobacter ilicis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0017
-
 3-hydroxy-2-methyl-1H-quinolin-4-one 30°C, pH 8.0 Paenarthrobacter ilicis
0.81
-
 O2 30°C, pH 8.0, with 3-hydroxy-2-methyl-1H-quinolin-4-one Paenarthrobacter ilicis

Organism

Organism UniProt Comment Textmining
Paenarthrobacter ilicis
-
 Rü61a
-
Paenarthrobacter ilicis Ru61a
-
 Rü61a
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-1H-quinoline-4-one + O2
-
 Paenarthrobacter ilicis N-formylanthranilate + CO
-
 ?
3-hydroxy-1H-quinoline-4-one + O2
-
 Paenarthrobacter ilicis Ru61a N-formylanthranilate + CO
-
 ?
3-hydroxy-2-methyl-1H-quinolin-4-one + O2
-
 Paenarthrobacter ilicis N-acetylanthranilate + CO
-
 ?
3-hydroxy-2-methyl-1H-quinolin-4-one + O2
-
 Paenarthrobacter ilicis Ru61a N-acetylanthranilate + CO
-
 ?

Synonyms

Synonyms Comment Organism
HodC
-
 Paenarthrobacter ilicis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
35
-
 3-hydroxy-2-methyl-1H-quinolin-4-one 30°C, pH 8.0, at 0.12 mM O2 Paenarthrobacter ilicis
145
-
 3-hydroxy-2-methyl-1H-quinolin-4-one 30°C, pH 8.0, at 0.96 mM O2 Paenarthrobacter ilicis