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Literature summary for 1.13.11.5 extracted from

  • Knox, W.E.; Edwards, S.W.
    Homogentisate oxidase of liver (1955), J. Biol. Chem., 216, 479-487.
    View publication on PubMed
Search for more literature for 1.13.11.5

Activating Compound

Activating Compound Comment Organism Structure
ascorbate activates Rattus norvegicus
cysteine activates Rattus norvegicus
glutathione activates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2,2'-dipyridyl complete inhibition Rattus norvegicus
azide
-
 Rattus norvegicus
benzoquinoneacetic acid
-
 Rattus norvegicus
cyanide
-
 Rattus norvegicus
cysteic acid weak inhibition Rattus norvegicus
cysteine inhibition not reversed by glutathione Rattus norvegicus
cystine inhibition not reversed by glutathione Rattus norvegicus
diphosphate
-
 Rattus norvegicus
Hg2+ inhibition reversed by glutathione Rattus norvegicus
p-chloromercuribenzoate inhibition reversed by glutathione Rattus norvegicus
phosphate
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ contains non-porphyrin iron, valence change of enzymic iron during reaction: ferric and ferrous iron Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
homogentisate + O2
-
 Rattus norvegicus 4-maleylacetoacetate product is 4-maleylacetoacetate, which is converted by a specific cis-trans isomerase to 4-fumarylacetoacetate ?
additional information enzyme contains essential sulfhydryl groups Rattus norvegicus ?
-
 ?