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Literature summary for 1.13.11.5 extracted from

  • Mendez, V.; Agullo, L.; Gonzalez, M.; Seeger, M.
    The homogentisate and homoprotocatechuate central pathways are involved in 3- and 4-hydroxyphenylacetate degradation by Burkholderia xenovorans LB400 (2011), PLoS ONE, 6, e17583.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
genes hmgA1 and hmgA2, the gene cluster hmgABC is located at C1 in strain LB400 genome, quantitative expression analysis Paraburkholderia xenovorans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
homogentisate + O2 Paraburkholderia xenovorans
-
4-maleylacetoacetate
-
?
additional information Paraburkholderia xenovorans LB400 cells grown with 3-hydroxyphenylacetate degrade homogentisate and show homogentisate 1,2-dioxygenase, EC 1.13.11.5 activity ?
-
?

Organism

Organism UniProt Comment Textmining
Paraburkholderia xenovorans
-
genes hmgA1 and hmgA2
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:3-hydroxyphenylacetate-grown cell
-
Paraburkholderia xenovorans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
homogentisate + O2
-
Paraburkholderia xenovorans 4-maleylacetoacetate
-
?
additional information LB400 cells grown with 3-hydroxyphenylacetate degrade homogentisate and show homogentisate 1,2-dioxygenase, EC 1.13.11.5 activity Paraburkholderia xenovorans ?
-
?

Synonyms

Synonyms Comment Organism
homogentisate 1,2-dioxygenase
-
Paraburkholderia xenovorans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Paraburkholderia xenovorans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Paraburkholderia xenovorans

Expression

Organism Comment Expression
Paraburkholderia xenovorans induction of fumarylacetoacetate hydrolase HmgB in Burkholderia xenovorans LB400 during growth on hydroxyphenylacetates additional information
Paraburkholderia xenovorans LB400 cells grown with 3-hydroxyphenylacetate degrade homogentisate and show homogentisate 1,2-dioxygenase activity. The hmgA1 gene is upregulated by 3-hydroxyphenylacetate in strain LB400. The expression of the hmgA2 gene is induced in 3-hydroxyphenylacetategrown-cells up